Yet, the mice fed a 0.1% or 0.5% 6′SL supplemented diet were found to have increased levels of IFNγ present in lung tissue, shifting the balance towards Th1 dominant cytokine production, which may have counteracted the effect of type 2 cytokines in chronic inflammation and airway hyperresponsiveness (69). This evidence concerns the gene IFNG and airway hyperresponsiveness.