To determine whether pan-TREM-1 and macrophage-restricted TREM-1 blockade alone or in combination with immune checkpoint blockade (ICB) are similarly effective against cancer in fully immunocompetent mice, C57BL/6 WT mice with orthotopically inoculated KPC tumor were treated with GF9 or GA31-LPC alone or in combination with anti-PD-L1 antibody. The gene discussed is PCSK7; the disease is cancer.