To the best of my knowledge, this is the first time that the efficacy of pharmacological blockade of TREM-1 in animal models of cancer and inflammatory diseases has been demonstrated to depend firstly, on the specificity of TREM-1 inhibitor (pan-TREM-1 or macrophage-restricted TREM-1 inhibitor) and secondly, on the timing of treatment initiation. The gene discussed is TREM1; the disease is cancer.