Ki-67 immunostaining for proliferation; Flow cytometry for G0/G1 arrest; DiD dye-retention assay for dormancy; Western blot for p21, p27, β-catenin, SIAH2; Genetic manipulation via Wnt5a knockdown and ROR2/SIAH2 silencing; In vivo validation using DiD-labeled, luciferase-expressing PCa cells injected into mouse tibiae; Bioluminescence imaging and bone lesion scoring for metastasis evaluation. This evidence concerns the gene CDKN1B and posterior cortical atrophy.