Exosomes derived from pancreatic ductal adenocarcinoma (PDAC) cells, enriched with MIF, activate Kupffer cells and induce the release of TGF-β. This cytokine, in turn, stimulates hepatic stellate cells to secrete fibronectin, thereby facilitating metastatic progression, as demonstrated through combined human and mouse in vivo studies. This evidence concerns the gene MIF and pancreatic ductal adenocarcinoma.