NR2F1 and head and neck squamous cell carcinoma: Notably, both AZA combined with atRA and AZA combined with AM80 have shown significant potential in inhibiting the formation of lung metastases in HNSCC by inducing and maintaining solitary DTCs in a SMAD4+/NR2F1+ dormant state, as demonstrated by in vitro cell line and in vivo mouse models (174).