Upregulated genes were primarily associated with cell adhesion/invasion/metastasis (ELMO2, ADAM9, DLG1, TRPM7), metabolism/mitochondrial function (FAM120A, DARS2), and cellular transport/axonal trafficking (KIF1B, TBC1D5), indicating the presence of tumor microenvironment stress. The gene discussed is DARS2; the disease is neoplasm.