Downregulated genes included those related to DNA repair/tumor suppression (HTATIP, PDCD4, ERCC2), autophagy/protein degradation (FBXW9, TRIM63, CHMP6, TBC1D14), transcription factors/cell cycle regulation (CREB3L4, TLE3, ZNF226, ZNF629, TFDP2, ZNF496), cytoskeletal/signaling processes (ARHGAP4, KIF25, ARL16), metabolic pathways (PEX16, CKB, MT1F, MRPL21), and immune/cancer antigen-related functions (CCR3, PELI2, BTN2A2, CTAG1A). The gene discussed is FBXW9; the disease is neoplasm.