Among these metabolites, 8-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid belongs to the PPAR signaling pathway; PC(18:1(11Z)/18:3(6Z,9Z,12Z)) and LysoPC(18:3(6Z,9Z,12Z)/0:0) are involved in choline metabolism in cancer; 2-hydroxycinnamic acid, N-acetyl-L-phenylalanine, phenylacetylglycine, and phenylacetylglutamine are associated with phenylalanine metabolism. The gene discussed is PPARA; the disease is cancer.