It was also found that high-risk tumors present a characteristic immune microenvironment: although there are cytotoxic phenotypes such as enhanced CD8 T cell infiltration, adaptive immune resistance driven by high-frequency mutations in TP53 (Figures 6G, H) and accompanying genomic instability (TMB↑) and enhanced tumor stemness (Figure 6E) lead to significant deterioration in survival outcomes. This evidence concerns the gene CD8A and neoplasm.