Mechanistically, Ythdf1-deficient tumors exhibit enrichment of mature DCs (↑MHC-II, ↑IL-12), enhanced CD4+/CD8+ T-cell infiltration, and increased IFN-γ production, while activating the tumor cell IFN-γR1–JAK/STAT1 pathway, thereby heightening susceptibility to immune clearance. The gene discussed is IFNG; the disease is neoplasm.