Moreover, the inhibition of TFAM expression facilitates the release of mtDNA into cytoplasm, and activates signaling pathways to modulate oncogenesis and it is crucial to develop novel small-molecule compounds to target mitochondrial RNA polymerase (POLRMT) to block mitochondrial transcription, thereby selectively blocking OXPHOS and curbing tumor cell proliferation in chemoresistant metastatic CRCs. This evidence concerns the gene POLRMT and neoplasm.