METTL3 and colorectal carcinoma: Concurrently, m6A RNA methylation regulators, including METTL3 and YTHDC1, orchestrate post-transcriptional control of metastasis-associated transcripts such as NRXN3, forming a METTL3–YTHDC1–NRXN3 axis that facilitates peritoneal dissemination of CRC (37, 38).