Differential expression analysis of GEO datasets revealed significant downregulation of ACTN4, CAPZB, CD2AP, DSTN, GYS1, LRPPRC, MYL6, PDLIM1, RPN1, and SLC3A2 in MM tissues compared with controls, whereas ACTB, FLNA, FLNB, INF2, IQGAP1, MYH9, NCKAP1, NUBPL, and SLC7A11 were upregulated (Figure 2F), implicating DRGs in MM pathogenesis. The gene discussed is PDLIM1; the disease is Miyoshi myopathy.