Among the nine signature genes, three (ANXA2, HIF1A, and MAST4) have been previously implicated in MM (42–44), whereas the remaining six (MCPH1, TPST2, RANGAP1, KIF21B, ALG14, and PQLC3) remain largely uncharacterized in this context. Here, RANGAP1 is linked to Miyoshi myopathy.