Differential expression analysis of GEO datasets revealed significant downregulation of ACTN4, CAPZB, CD2AP, DSTN, GYS1, LRPPRC, MYL6, PDLIM1, RPN1, and SLC3A2 in MM tissues compared with controls, whereas ACTB, FLNA, FLNB, INF2, IQGAP1, MYH9, NCKAP1, NUBPL, and SLC7A11 were upregulated (Figure 2F), implicating DRGs in MM pathogenesis. This evidence concerns the gene IQGAP1 and Miyoshi myopathy.