The International Kidney and Monoclonal Gammopathy Research Group classified LHCDD within monoclonal gammopathy of renal significance (MGRS), including a spectrum of kidney disorders caused by a monoclonal protein (M-protein) secreted by a small plasma cell clone or other B-cell clones in patients who do not meet the diagnostic criteria for multiple myeloma or other B-cell malignancies (2). This evidence concerns the gene MYOM2 and AL amyloidosis.