It was characterized by the co-enrichment of canonical mitotic regulators, including MKI67 (27, 28), TOP2A (29, 30), ASPM (31), NUSAP1 (32), UBE2C (33), CENPF (34), CENPE (35), and TTK (36) consistently ranking among the top-scoring contributors, all of which have been extensively validated in prior literature as indispensable for cell proliferation across multiple cell types and cancer contexts. This evidence concerns the gene TOP2A and cancer.