CENPE and cancer: It was characterized by the co-enrichment of canonical mitotic regulators, including MKI67 (27, 28), TOP2A (29, 30), ASPM (31), NUSAP1 (32), UBE2C (33), CENPF (34), CENPE (35), and TTK (36) consistently ranking among the top-scoring contributors, all of which have been extensively validated in prior literature as indispensable for cell proliferation across multiple cell types and cancer contexts.