For example, using a lipid nanoparticle (LNP) delivery system to administer dual mRNA encoding lysosomal cysteine protease Legumain and antifibroblast activation protein (FAP) CAR directly to the infarct zone can reprogram macrophages on site, generating “efferocytosis‐enhanced, FAP‐targeted CAR‐MΦ, ” which significantly improves the treatment efficacy of MI fibrosis [158]. Here, FAP is linked to myocardial infarction.