Thrombin–antithrombin complex (TAT), a2-plasmininhibitor–plasmin complex (PIC), thrombomodulin (TM), tissue plasminogen activator–plasminogen activator inhibitor complex (t-PAIC) has been increasingly applied in clinical practice in recent years, especially in the diagnosis and treatment of diseases associated with thrombosis and hemorrhage. This evidence concerns the gene PLG and Venous thrombosis.