Thrombin–antithrombin complex (TAT), a2-plasmininhibitor–plasmin complex (PIC), thrombomodulin (TM), tissue plasminogen activator–plasminogen activator inhibitor complex (t-PAIC) has been increasingly applied in clinical practice in recent years, especially in the diagnosis and treatment of diseases associated with thrombosis and hemorrhage. The gene discussed is THBD; the disease is deep vein thrombosis.