SERPINE1 and infection: Numerous studies have confirmed that TM levels can significantly increase in many inflammatory conditions.5Tissue plasminogen activator–plasminogen activator inhibitor complex (t-PAIC) is a complex formed when t-PA (tissue plasminogen activator) and PAI-1 (plasminogen activator inhibitor-1) are released into the blood during endothelial cell injury, which has high diagnostic value for severe infection.