MAPT and Anxiety: This model of LC hyperactivity predicts that as establishment of hyperphosphorylated tau within the LC results in increased neuronal activity causing pre-MCI (“prodromal”) symptoms, such as anxiety, hyperarousal (Kelberman et al., 2023; Kelberman et al., 2022), and in humans, aggression (Bachman and Rabins, 2006; Ballard and Corbett, 2013; Scarmeas et al., 2007).