Importantly, however, lower LC integrity as measured by LC-MRI is correlated with greater cortical tau pathology as measured by PET, as well A-β and cognitive measures (Jacobs et al., 2022), and lower regional cortical glucose metabolism as measured by [18F]FDG in individuals with dementia and MCI (Aghakhanyan et al., 2023), and this is correlated with cognitive performance in patients with AD (Khosravi et al., 2019). This evidence concerns the gene MAPT and Alzheimer disease.