This study examined the prevalence of silent brain infarcts in each group after adjusting for demographic, vascular, and inflammatory confounders -age, sex, current smoking, current alcohol use, anti-platelet agents, high-sensitivity, C-reactive protein (CRP), and white blood cell counts, and found that metabolic status, but not obesity status, was associated with prevalence and burden of silent brain infarcts (i.e., higher burden in MUO/MUL relative to MHL, with no difference between MHO and MHL). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.