Interestingly, elevated markers of systemic inflammation (such as IL-6 and CRP) have been linked to increased dementia risk (Yaffe, 2007; Yaffe et al., 2004), even decades prior to its occurrence (Schmidt et al., 2002), possibly due to accelerated accumulation of amyloid-β (Abdallah et al., 2021; Keaney et al., 2015; Ma et al., 2018). This evidence concerns the gene IL6 and dementia.