Using the NCEP-ATP III definition of MHO, they reported that the MHO subjects (defined using the NCEP-ATP III criterion) showed a decreased AD risk compared with their lean counterpart (MHL), after adjustment for age, sex, genetic (APOE ε4) predisposition to dementia, cognitive diagnosis, education, tobacco use, alcohol consumption and LDL-cholesterol (Ma et al., 2019). This evidence concerns the gene APOE and Alzheimer disease.