Other MHO definitions, such as the one by Karelis et al. (2005) - based primarily on markers of insulin sensitivity, inflammation and lipid profile – and the one by Wildman (2008) - based on markers of the metabolic syndrome combined with the homeostasis model assessment of insulin resistance (HOMA-IR index) – exist, but have not been widely adopted in neuroimaging literature. This evidence concerns the gene INS and Insulin resistance.