Elbeyli et al showed that elevated SII was strongly associated with diabetic macular edema in patients with non-proliferative diabetic retinopathy, in which systemic and retinal inflammations play a role.[27] Wang et al found that NLR and SII values were noticeably positively correlated with interleukin-6 (IL-6) levels in the aqueous humor of young patients with ischemic retinal vein occlusion. This evidence concerns the gene IL6 and diabetic macular edema.