Although the role of MED13L in congenital heart disease has been reported by several research studies, increasing clinical and experimental evidence has successively demonstrated the vital role of MED13L in the regulation of the neural crest cells and neurogenesis, along with its morphological and functional impacts on cortical neurons, which may exert great influence on intellectual development (Muncke et al., 2003; Angus and Nevins, 2012; Asadollahi et al., 2017; Hamada et al., 2023). This evidence concerns the gene MED13L and congenital heart disease.