A number of studies revealed the effect of SRPK inhibition on metastatic abilities using the scratched wound assay in A375 cells after the knockdown of SRPK1, and showed a reduction in migrating ability.16 In B16F10 murine melanoma cells, SRPIN340 treatment demonstrated inhibitory effects on migration, invasion, and adhesion abilities.18 In addition, SPHINX31 treatment showed significantly slower migration ability in A375 cells.33 In this study, suppression of the invasion ability of A375 cells using the transwell invasion assay was verified. This evidence concerns the gene SRPK1 and melanoma.