On the other hand, to explore the death induction effects of SRPK inhibition, SRPIN340 and SPHINX31 increased the number of Annexin V-positive NK/T-cell lymphoma cells, which also marked the upregulation of cleaved PARP and cleaved caspase-3.35 In mice, SRPIN340 treatment in tumor melanoma increased caspase-3-positive cell counts.36 This study presented higher apoptotic cell populations as counted in SRPIN340 treatment than in SPHINX31 treatment (Figure 3A-C). The gene discussed is ANXA5; the disease is T-cell non-Hodgkin lymphoma.