FLT4 and lymphedema: This approach maximizes drug efficacy, enhances VEGF-C/VEGFR-3-driven lymphangiogenesis, and minimizes systemic side effects, offering a precise intervention for lymphatic vessel repair.55 By integrating metabolic and vascular repair mechanisms, GLP-1RAs could redefine lymphedema management, transforming it from a symptom-driven approach to one that targets its metabolic roots, paving the way for personalized and effective therapies.