These include ERα-negative regulators such as miR-342,33 Let-7b/Let-7i,34 and miR-1280.35 Additionally, miRNAs targeting ERα coactivators/corepressors are involved: miR-17-5p regulates SRC-336; miR-10 targets the nuclear corepressor NCOR2;16 miR-451 regulates HER2, EGFR, and MAPK signaling12; and miR-101 influences Akt signaling in resistant cells.13 Among tumor suppressors, PTEN is particularly notable as a frequent miRNA target linked to hormonal resistance.37-39 Several of these miRNAs are known to be exosome-transported, supporting their role in resistance transfer.40,41. The gene discussed is ESR1; the disease is neoplasm.