Our results are consistent with the data of other researchers who have demonstrated the increase in Snail level in the miR-181-overexpressed cells.51-53 Partially, the recent observations have shown the ability of miR-181a, along with TMBIM6 protein, to increase Snail level through the activation of ERK pathway in breast cancer cells.51 The gene discussed is TMBIM6; the disease is breast cancer.