Image analysis further confirmed elevated ERBB2 expression, with estrogen receptor (ER) scores of 4 + and 7 + observed in approximately 30% (weak positive) and 80% (moderate positive) of tumor cells, respectively, and progesterone receptor (PR) scores of 7 + in 80% of tumor cells by nuclear staining (Figure 3). The gene discussed is ESR1; the disease is neoplasm.