In this regard, new therapeutic protocols with fewer side effects are mandatory.2 Among different BC types, triple-negative BC (TNBC) is highly aggressive with rapidly proliferating tumor cells that promote the formation of metastatic foci.3,4 TNBC cells lack typical membrane-bound hormone receptors such as estrogen, progesterone, and HER-2 receptors, with inherent resistance against chemotherapeutics.5 It is thought that these features are closely associated with the existence of distinct subsets, namely cancer stem cells (CSCs) within the tumor parenchyma. The gene discussed is NR4A1; the disease is neoplasm.