Recent data confirmed that the stimulation of the TLR4 signaling pathway can contribute to inflammatory angiogenesis response in different cells.46 The activity of NF-κB is integral to angiogenesis properties in the host cells.47 As a common belief, the blockade of NF-κB coincides with the reduction of angiogenesis in different cells, especially tumor cells.48 However, in the present study, this activation did not influence the expression of HIF-1α and VEGF as early-stage angiogenesis cytokines. Here, TLR4 is linked to neoplasm.