TLR4 and neoplasm: The formation of new vascular beds inside the cancers contributes to rapid tumor cell expansion and metastasis to the neighboring tissues and remote organs.18,19 Exos with different molecular cargoes can control the phenomenon of neovascularization into the tumor structure.15,20,21 While TLR4 has been implicated in Exo production, its influence on the angiogenic potential of TNBC remains unclear.