These findings align with the research by Hou et al., which showed that CE extract (150 mg/kg, IV) alleviated depression-like behaviors in rats subjected to chronic stress for 21 days and resulted in decreased levels of IL-1β and TNF-α cytokines.33 Quercetin, a key component of CE extract, is vital for its anti-inflammatory potential. The gene discussed is TNF; the disease is major depressive disorder.