ACSL4 and laryngotracheoesophageal cleft: In cisplatin-resistant laryngeal cancer (LC), RBM15 is upregulated, and its silencing decreases the IC50, suppresses cell viability and proliferation, elevates Fe^2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels, and increases ACSL4 expression, thereby inducing ferroptosis.