CBR3 and non-small cell lung carcinoma: Moreover, in NSCLC, RBM15 facilitates radioresistance through an m6A-IGF2BP3-dependent mechanism that upregulates CBR3-AS1, which in turn regulates the miR-409–3p/CXCL1 axis, promoting myeloid-derived suppressor cell (MDSC) recruitment and suppressing T cell activity (Hu et al., 2025).