Mutations in DGCR8 are observed in thyroid cancer (Paulsson et al., 2021; Rodrigues et al., 2024; Rodrigues et al., 2022), and mutations in both DROSHA and DGCR8 occur in Wilms’ tumor (Rakheja et al., 2014; Walz et al., 2015), highlighting the importance of maintaining Microprocessor integrity. The gene discussed is DGCR8; the disease is thyroid cancer.