KDM5B and atherosclerosis: We found that disturbed flow, a pro-atherogenic force, upregulates the expression of the histone demethylase KDM5B via the Piezo1-ETS-1/c-JUN pathway and that KDM5B then downregulates H3K4me3 at anti-inflammatory gene promoters, exacerbating endothelial inflammation and atherosclerosis (Wu et al., 2024a).