By integrating Fructus Xanthii’s 1,317 predicted targets with the asthma-related genes, we identified 100 overlapping targets, which were significantly enriched in pathways related to steroid hormone response (e.g., glucocorticoid receptor NR3C1), kinase activity (e.g., HSP90AB1), and immune modulation. The gene discussed is NR3C1; the disease is asthma.