AKBA250 administration demonstrates its antioxidant potential by increasing Nrf2 nuclear translocation, which is reflected in its downstream molecule HO-1 levels, and these results are consistent with previous findings in obsessive-compulsive disorder and experimental autoimmune encephalomyelitis models (Sethi et al., 2023; Nadeem et al., 2022). Here, NFE2L2 is linked to experimental autoimmune encephalomyelitis.