In OA, chondrocyte necroptosis accelerates cartilage degradation and synovial inflammation through the activation of the receptor-interacting protein kinase 1 (RIPK1)/receptor-interacting protein kinase-3 (RIPK3)/mixed lineage kinase domain-like protein (MLKL) signaling cascade, which compromises membrane integrity and amplifies local inflammatory signaling (Jeon et al., 2020). The gene discussed is RIPK1; the disease is inflammation.