ZBTB16 and periodontitis: Meanwhile, ZBTB16 (zinc finger and BTB domain-containing 16) showed the strongest evidence of association with severe periodontitis (rs454802, p = 2.2x10<sup>-7</sup>).<h4>Conclusions</h4>This study's results emanate from a well-characterized cohort of periodontitis severity and progression and add to the knowledge base of periodontal genomics and the underlying individual disease susceptibility.<h4>Plain language summary</h4>This study assessed the association of gene variants in association with gum disease severity and progression in 416 participants of a clinical study.