TBR1 and Anxiety: For example, upregulated genes include TBR1, a key regulator of cortical development (Hevner et al. 2001); NPTX2, neuronal pentraxin for synaptic plasticity (Zhou et al. 2023); neuropeptide S receptor NPSR1 in neuroendocrine cells (Pulkkinen et al. 2014); ADRA2B, which regulates neurotransmitter norepinephrine (Xie et al. 2018); ADORA2A, linked to anxiety, arousal, and sleep regulation (Hohoff et al. 2020).