Similar to alpha-1-antichymotrypsin, alpha-1-antitrypsin has been implicated in various ocular diseases, including keratitis, diabetic retinopathy, age-related macular degeneration, glaucoma, cataracts, dry eye disease, keratoconus, uveitis and pterygium [67]. Here, SERPINA3 is linked to age-related macular degeneration.