Similar to alpha-1-antichymotrypsin, alpha-1-antitrypsin has been implicated in various ocular diseases, including keratitis, diabetic retinopathy, age-related macular degeneration, glaucoma, cataracts, dry eye disease, keratoconus, uveitis and pterygium [67]. The gene discussed is SERPINA1; the disease is diabetic retinopathy.