NR3C1 and pulmonary arterial hypertension: In line with our previous results, pathway mapping using the WikiPathways database corroborated these findings, revealing a significant downregulation of VEGFA-VEGFR2 signaling, cytokine-cytokine receptor interactions, prostaglandin synthesis, interferon signaling, and glucocorticoid receptor pathways (Fig. 3F, right panel), all of which are known to contribute to vascular inflammation and remodeling in PAH.