In line with our previous results, pathway mapping using the WikiPathways database corroborated these findings, revealing a significant downregulation of VEGFA-VEGFR2 signaling, cytokine-cytokine receptor interactions, prostaglandin synthesis, interferon signaling, and glucocorticoid receptor pathways (Fig. 3F, right panel), all of which are known to contribute to vascular inflammation and remodeling in PAH. Here, VEGFA is linked to pulmonary arterial hypertension.