In contrast, the frequencies of monocytes and dendritic cells within the tumor tissue remained unchanged following treatment (Fig. S3h-k), demonstrating that the PD-L1 × CD47 aptamer-siRNA chimera primarily exerts its immunological effects through selective depletion of Treg cells, enhanced effector function of CD8+ T cells, and increased phagocytic capacity of macrophages. The gene discussed is CD8A; the disease is neoplasm.