To further elucidate the underlying mechanisms of microglial Hv1 in AD pathologies, we analyzed microglial transcriptomic data and found that the ETC, a crucial mitochondrial component responsible for energy production and redox homeostasis, was extensively damaged in both the AAV-TAU and 3×Tg mouse models (Fig. 5a,b and Supplementary Fig. 6a). The gene discussed is HVCN1; the disease is Alzheimer disease.