CSDC2 and Alzheimer disease: Of note, a striking downregulation was observed for Cold Shock Domain Containing C2 (Csdc2), an RNA-binding protein, Reelin, an extracellular matrix glycoprotein linked to synaptic integrity and cognitive resilience to AD, as well as proteins involved in proteosomal (Psmd12) and lysosomal (Rab32a) activity.