TREM2 and Alzheimer disease: Moreover, when we assessed inflammatory-related markers in cortex by qPCR, there was an effect of AD genotype (p < 0.01) and igf1r genotype (p < 0.01) for gfap (Fig. 6C), no differences in iba1 (Fig. 6D), but an igf1r genotype effect for trem2 (Fig. 6E; p < 0.01) and il6 (Fig. 6F; p < 0.01) where levels were reduced in igf1r Hets.