Similarly, while no differences were observed in hippocampal GFAP counts among groups (Fig. 6G; p < 0.001), a significant main effect of AD genotype (p < 0.01), igf1r genotype (p < 0.0001) and interaction term (p < 0.01) was observed for GFAP in cortex (Fig. 6H;, This corresponded with several interesting trends via qPCR in cortex, including for gfap (Fig. 6I; AD genotype p < 0.01), iba1 (Fig. 6J; igf1r genotype p < 0.01), trem2 (Fig. 6K; igf1r genotype p < 0.01) but not for il6 (Fig. 6L). The gene discussed is TREM2; the disease is Alzheimer disease.