Interestingly, while Igf1r heterozygosity resulted in a number of significantly up- and down-regulated proteins in WT (non-AD) males (Fig. S4D), only one protein, Rpl29, was significantly regulated in female Het hippocampus (Fig. S4E), and these results led to disparate effects via pathway analysis in hippocampus of non-AD male and female animals, respectively (Fig. S4F,G). Here, IGF1R is linked to Alzheimer disease.