In contrast, proteins such as RAS p21 protein activator 1 (Rasa1), a negative regulator of Ras-MAPK signaling, Neuronal Growth Regulator 1 (Negr1), as well as proteins involved in ER stress, (Tmem33), and G Protein signaling (Gna14; Rit2) were all significantly upregulated in AD Hets. This evidence concerns the gene TMEM33 and Alzheimer disease.