Consistent with our initial observations, Igf1r Heterozygosity reduced body weight in WT control and TgF344-AD rats of both male (Fig. 4A; p < 0.001) and female (Fig. 4C; p < 0.001) rats, along with lower IGF-1R levels in cortex in both sexes (Fig. 4B,D; p < 0.001), regardless of control or TgF344-AD genotype. Here, IGF1R is linked to Alzheimer disease.