Strong pairwise interactions involving CENPA-MYBL2, and CENPA-RRM2 were identified in the prim/norm and mCRPC/mHSPC transitions (Fig. 8d, f and Supplementary Fig. S4), highlighting their predictive association and providing insights into potential functional dependencies of these genes during tumor initiation and castration resistance. This evidence concerns the gene MYBL2 and neoplasm.