TPX2 and posterior cortical atrophy: To gain a broader understanding of TPX2-associated networks, we performed functional enrichment analysis of DEGs within TPX2-centered clusters for each comparison using the REACTOME database (Supplementary Table S7).We identified 20 shared REACTOME pathways among modules M3 (prim/norm), M2 (mHSPC/prim) and M1 (mCRPC/mHSPC), which were mainly associated with mitosis, cell cycle and transcriptional regulation (Fig. 6c, d) highlighting these essential molecular mechanisms to be consistently deregulated across all disease stages, reinforcing their central role for PCa progression.