Several of these genes have established roles in HNSCC pathogenesis; for example, RPL30 has been implicated in promoting invasion and metastasis in oral squamous cell carcinoma,37 HDAC9 overexpression is associated with increased tumor growth and cell cycle progression,38 and KEAP1 inhibition sensitizes HNSCC cells to ionizing radiation by impairing non-homologous end joining and inducing autophagy.39 The gene discussed is KEAP1; the disease is oral cavity squamous cell carcinoma.