LOXL2 and head and neck squamous cell carcinoma: Similarly, Ding et al. developed multiple splicing prognostic signatures—including one integrating all 7 AS types—highlighting the prognostic value of AS events and splicing factors (SFs).33, 34, 35 While previous research has examined specific splice variants in HPV-negative HNSCC, such as DOCK5 and LOXL2 variants,10,36 comprehensive evaluation of splicing events in this subset has been limited.