The pathogenic genome rate of fetal pericardial effusion was 7.9% (11/140), including 3 cases of trisomy 21 syndrome, 2 cases of Turner syndrome, 2 cases of large fragment deletion, 3 cases of microdeletion, and 1 case of a single gene mutation (PLD1 gene mutation). This evidence concerns the gene PLD1 and pericardial effusion.