SERPINF1 and osteoarthritis: Among participants, those with a history of hypertension or osteoarthritis had significantly higher age-adjusted mean lnPEDF concentrations than those without these conditions (2.60 vs. 2.51, p = 0.027; 2.63 vs. 2.51, p = 0.007, respectively; Table 3), which may reflect a link between PEDF and metabolic or inflammatory processes associated with these conditions.