Estrogen loss promotes the buildup of visceral fat, which drives insulin resistance and inflammation, up-regulates hepatic insulin clearance, predisposing to hyperglycemia, decreases lipoprotein lipase activity, thereby inducing dyslipidemia, and impairs endothelial function by reducing nitric oxide synthase-mediated vasodilation, culminating in elevated blood pressure [8–11]. Here, INS is linked to metabolic syndrome.