CD40LG and autoimmune disease: Natural IgM plays multiple roles in homeostasis, including scavenging and clearance of apoptotic cell debris in conjunction with phagocytic macrophages, B cell survival through tonic signals, lymphoid tissue architecture, and prevention of autoimmune diseases (Ehrenstein and Notley, 2010; Michaud et al., 2020; Quartier et al., 2005).