For instance, the El-porCEA vaccine (NCT01064375) targets colorectal cancer using a plasmid DNA encoding carcinoembryonic antigen (CEA) fused with a tetanus toxoid helper epitope, while GX-188E (NCT01634503) and VGX-3100 (NCT03185013, NCT01304524) target HPV-16 and HPV-18 in cervical neoplasia.30,31 Similarly, INVAC-1 (NCT02301754)32 encodes the human telomerase reverse transcriptase (hTERT), over-expressed in most cancers, and INO-5150 (NCT02514213) combines prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) sequences to elicit prostate cancer immunity. This evidence concerns the gene CEACAM5 and colorectal cancer.