RAB7A and Autosomal dominant Charcot-Marie-Tooth disease type 2B: These trafficking defects are reminiscent of some aspects of the Charcot-Marie-Tooth type 2B disease, a peripheral axonal neuropathy caused by missense mutations in the RAB7 gene (Spinosa et al., 2008; McCray et al., 2010; Zhang et al., 2013).