He presented with polyuria, polydipsia, and confusion, required prolonged insulin infusion for glucose stabilization, and was discharged on basal-bolus insulin therapy after drug discontinuation.15) These reports indicate that, although rare, AKT-inhibitor–induced hyperglycemia can occasionally present as life-threatening DKA, underscoring the need for early detection and prompt management. This evidence concerns the gene AKT1 and Polyuria.