IDH1 and neoplasm: Molecular profiling of Western intrahepatic iCCA cohorts reveals IDH1 genomic alterations in 13% of cases and FGFR2 fusion events in 8%–14%.32, 33, 34 In this study, we detected an FGFR2 fusion in both tumor tissue and matched bile samples, while it was undetectable in plasma cfDNA.