Karnati et al. observed a significant reduction in CLDN1 expression in glioblastoma (grade 4) and anaplastic astrocytoma (grade 3) tumor samples, compared to pilocytic astrocytoma (grade 1) and diffuse astrocytoma (grade 2) samples, in which CLDN1 expression was elevated (33). The gene discussed is CLDN1; the disease is anaplastic astrocytoma.