Shaikh et al. observed that stress contributes to an increase in pro-inflammatory cytokines in IBS patients, as psychological stress can trigger increased production of inflammatory cytokines through the hypothalamic-pituitary-adrenal (HPA) axis via the release of CRH and, consequently, adrenocorticotropic hormone and cortisol [12]. The gene discussed is CRH; the disease is irritable bowel syndrome.