Watts et al. reported that punctuate IgG deposition was IgG1 or IgG4 in minimal change disease [3]. Shirai et al. reported that diverse IgG class patterns were present in cases of recurrent FSGS after kidney transplantation [4]. Further research is needed to assess the relationship between IgG subclass pattern and clinical findings and prognosis in anti-nephrin antibody-associated minimal change disease or FSGS. The gene discussed is NPHS1; the disease is lipoid nephrosis.