PHGDH and myocardial infarction: Despite the inherent limitations associated with the partial representation of the arterial proteome in peripheral blood plasma, our data reveal that specific mitochondrial metabolic proteins namely succinyl-CoA ligase subunit alpha, malate dehydrogenase, and the alpha and beta subunits of hydroxyacyl-CoA dehydrogenase are detectably released into circulation following myocardial infarction.