CD8A and cancer: Notably, the metabolic tug-of-war between cancer cells and antitumor T cells in the obese CRC microenvironment showed that cancer cells could upregulate fatty acid transport proteins (FATPs) to uptake and deprive free fatty acids, but CD8+ T cells could not, which results in fatty acids in the tumor microenvironment (TME) being depleted and T cells becoming dysfunctional due to a lack of this essential fuel [17].